COMPARATIVE EFFECTIVENESS OF TREATMENT OF INFLAMMATORY-PURULENT PROCESSES OF THE LIMB DISTAL SEGMENT IN PIGS

Abstract

The article materials are devoted to the development of effective, scientifically grounded treatment
schemes of inflammatory-purulent processes of limb distal segment in pigs. The aim of the article is to compare
the classical and experimental treatment schemes of separate nosological forms of pig limb distal segments
in the comparative aspect, to define the peculiarities of medical preparation action on the blood indices
of diseased pigs. The task was to conduct approbation of treatment schemes of pigs suffering from inflammatory-
purulent processes of limb distal segment; to define separate morphological, biochemical, immunological
indices of blood before and in the process of treatment. Clinical, hematological, immunological,
and biochemical methods were used during the work. As a result, it was established that there was the increase
in the number of leukocytes and the erythrocyte sedimentation rate in diseased pigs. There was a shift
of the neutrophils nucleus to the left with the decrease in the number of lymphocytes in the leukogram. There
was also the decrease of the immunity activity in pigs. Immunodeficiency was due to a low content of immune
defense components and dysproteinemia. Increasing the level of hexoses, glycosaminoglycans, glycoproteins
and the concentration of sialic acids was registered in pigs suffering from inflammatory-purulent processes,
which indicated at involving the structural elements of connective tissue of the locomotorium in the inflammatory
process. The results of the conducted studies testify that the diseased animals have the increased content
of malonic dialdehyde and catalase activity, which is stipulated by activating the antioxidant system. The
deficit of calcium, phosphorus, vitamin A, and β-carotene was also registered. Taking into account the obtained
results of laboratory tests of the diseased animal’ blood, we suggested the treatment scheme that included
using medicinal preparations of pathogenetic action. Comparing the classical and experimental
treatment schemes, the peculiarities of medicinal preparations’ action on the blood indices of the diseased
pigs were established. In segmenticular, “Trifuzol 1 %” preparation increases the number of the immune
system specific components (T-cells and B-lymphocytes, the population of T-cells, NK-cells), stimulates the
metabolism of connective tissue and the antioxidant system of the body on the whole. Morphological, biochemical,
and immunological blood indices are also normalized, the recovery of pigs suffering from purulent-
inflammatory processes of the limb distal segment quickens.