Morphological and biochemical studies of the blood of invased dogs and cats in the process of using the drug "Brovanol-С"

Abstract

A significant number of drugs, including those for use in the fight against and prevention of invasive diseases in domestic carnivorous animals, produced by domestic and foreign manufacturers have registered on the veterinary goods market. The variety of types and forms of medicinal products, the presence on the market are not only original drugs that also their analogues manufacture by several enterprises, causes the emergence of a problem regarding the justified choice of products. The success of deworming animals depends on the availability of modern, highly effective, generally available, as well as low-toxic anthelmintics. The purpose of the research had been established the effect of domestically produced anthelmintic drug "Brovanol-C" (Brovafarma LLC, Ukraine) on the hematological parameters of dogs and cats during their treatment. During the presence of toxocarosis invasion drug on the seventh day of application for cats, a gradual recovery of morphological and biochemical indicators of blood to physiological limits has founded. The number of erythrocytes increased (by 13.35 %), the number of leukocytes decreased (by 6.43 %), the content of albumins increased (by 8.86 %) and glucose (by 29.88 %), and the activity of alkaline phosphatase decreased (by 12.61 %). When using "Brovanol-C" as a therapeutic agent, morphological and biochemical blood parameters was observed normalization in dogs infested with toxocaries and dipilidies. The increase in the number of erythrocytes (by 17.72%) and hemoglobin content (by 15.63%), decrease in the number of leukocytes (by 19.09%), increase in albumin content (by 18.55%) and glucose (by 30.20%), a decrease in the activity of alkaline phosphatase (by 10.28%) has detected during the treatment of sick dogs on the seventh day of the experiment. The content of creatinine, urea and the activity of ALT, AST in the blood serum of cats and dogs that were treated and that remained infested with helminths was not changed during the experiment. The obtained research results indicate the liberation of the animal body from helminths and the restoration of their homeostasis, which allows recommending this anthelmintic in the treatment and prevention of helminthiasis in cats and dogs.